BUP (semi-synthetic opioid) is a medication prescribed to individuals who are addicted or dependent on opioid drugs. BUP helps relieve withdrawal symptoms such as nausea, insomnia, agitation, etc. It is less addictive and the risk of overdose is low. The BUP effects last for approximately three days.
BUP is sold under different trade names in the form of tablets and patches, and these drugs are used in different stages of addiction treatment process as well as for maintenance treatment. Some of the side effects of BUP include nausea, headaches, flu-like symptoms, sweating, mood swings, etc. BUP taken in combination with alcohol or CNS depressants may induce severe breathing problems.
BUP drugs are classified as Schedule III with a moderate to low physical dependence, but may potentially have high psychological dependence.
BUP drug tests are frequently administered in individuals while recovering from opioid drug disorder to monitor sobriety.
- How Long Does BUP Stay in Your System?
- BUP Drug Test
- False Positive Testing
- Drug Interactions
How Long Does BUP Stay in Your System?
BUP is a partial agonist that activates the opioid receptors in the brain, leading to reduction in opiate withdrawal symptoms. This drug helps in avoiding the euphoric effects of opioid drugs by fulfilling the brain’s need for opioid.
After ingestion of BUP, it gets absorbed into the bloodstream. The liver breaks it down and releases it back into the bloodstream. The kidneys filter it and excrete it through urine.
The detection period for BUP varies from person to person and a variety of factors affect including:
- Height and weight
- Amount of BUP taken
- Frequency of drug use
- Fat content in the body
- Liver function
- Overall physical and mental health
- Rate of metabolism
- Time between the drug test and the BUP use
BUP Drug Test
BUP has a different metabolite that is not found in the most commonly abused opioids. This drug cannot be detected in any of the standard panels such as in employment. BUP can be detected by using a specific or targeted opioid urine screening test. Method of testing used to detect BUP is urine, blood, saliva and hair.
- Urine: This is the most commonly used type of testing method since it is easy to administer and inexpensive. BUP can be detected within less than an hour in the urine and for up to 6 days after last dose. It can be detected even up to 2 weeks in heavy users.
- Blood: Since blood tests are invasive and expensive, they are less frequently administered. BUP can be detected mostly within 2 to 12 hours after the last use and up to 2 days. Blood test has a shorter detection period; hence it is administered relatively quickly after the user has taken the last dose.
- Saliva: This test is easy to use and noninvasive, and has a slightly longer detection period than blood tests. Saliva test can detect BUP within a few minutes of ingestion. BUP can be detected in the saliva for up to 3 to 10 days after usage of the medication.
- Hair: There are research studies that BUP metabolites can be found in hair samples. Since the hair follicle testing has a longer detection window, BUP can be detected in the hair specimens for up to 3 months after the last usage.
Since BUP is frequently used to prevent withdrawal symptoms from opioid misuse, it is crucial for the labs to differentiate between the prescribed BUP use and over-the-counter opioid use.
False Positive Testing
Immunoassay is the most commonly used method of detection that can give false-positive drug test results. There are several medications that can trigger a false-positive result for BUP. These false positives are confirmed with second independent testing method such as gas chromatography-mass spectrometry (GC/MS) or liquid chromatography-tandem mass spectrometry (LC/MS/MS) to identify specific drugs of use.
It is highly recommended to disclose if you are taking any prescription or over-the-counter medications so that the clinicians can accurately interpret the drug testing results.
Clearing BUP Out of Your System
BUP is not screened as part of any standard panel, but if needed, it can be specifically tested such as in case of suspicion or clinical settings.
If you want to eliminate BUP out of your system, you need to first stop the medication under the appropriate guidance of your physician. Stopping this medication abruptly will lead to withdrawal symptoms.
You can also try to speed up your body metabolic rate by following healthy eating habits, regular exercise and drinking plenty of water.
- Many drugs are known to interact with BUP and cause severe side effects. You must inform your physician in case you are taking any other drug(s) for any medical condition(s) before starting BUP.
- Consuming alcohol or other antidepressants along with BUP may induce severe breathing problems as well as make you drowsy and dizzy.
- Older people may experience more side effects such as drowsiness, shallow breathing, confusion, etc.
- Misuse of BUP can be fatal leading to death.
BUP is a semi-synthetic opioid typically used to treat opioid dependence disorders. It helps people in slowly tapering off the dose, and also aids in minimizing or eliminating symptoms of withdrawal and cravings.
Being an opioid, BUP can still be abused to get the euphoric feeling. It won’t have an effect on people who are already addicted to opioids and have developed a tolerance. People who have never used any opioids may be susceptible to getting dependent on any of the BUP formulations.
BUP is not specifically tested as part of any standard employment drug testing. If you are undergoing treatment for opioid dependence, it might mimic other opioid substance and show up on the drug test panel. In such cases, you can divulge your prescription to the tester before taking the test.
Typically, BUP can be detected for 7 to 10 days and can vary according to a person’s individual factors such as age, weight, height, metabolism rate, amount of drug used and frequency, etc.
One should avoid taking BUP with any other medications, alcohol or antidepressants since it can increase or lead to severe adverse effects and can be fatal at times.